Yes, you can use one dehumidifier for the whole house.
But, if you want a dehumidifier to serve your entire house, you’ll need a whole-house dehumidifier. You can use this type as a portable unit. Or use it as an add-on to your existing central heating system, and it can handle up to 5000 square feet.
They are pricey, but they would do an outstanding job wherever they are. This allows you to use your air conditioner less. This is due to the high amount of moisture they remove, thereby saving energy and money.
Check out our best pick dehumidifier ALORAIR 55 Pint Dehumidifier.